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Title

Caffeine in Drug Cocktails: The Formation of “Water Pockets” in Membranes

Authors

Adree Khondker - McMaster University
Alexander K. Dhaliwal - McMaster University
Richard J. Alsop - McMaster University
Jennifer Tang - McMaster University
Matilda Backholm - Aalto University, Helsinki, Finland
An-Chang Shi - McMaster University
Maikel C. Rheinstadter - McMaster University

Abstract

This article reports on the biophysical consequences of induced hygroscopic “water pockets” in cell membranes by the small molecule caffeine to understand membranemediated drug interactions.